Reactive oxygen species and hematopoietic stem cell senescence
نویسندگان
چکیده
منابع مشابه
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells.
Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment (HM) control HSC activity during regenerative hematopoiesis. Connexin-43 (Cx43), a connexin constituent of gap junctions (GJs) is expressed in HSCs, down-regulated during differentiation, and postulated to be a self-re...
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ژورنال
عنوان ژورنال: International Journal of Hematology
سال: 2011
ISSN: 0925-5710,1865-3774
DOI: 10.1007/s12185-011-0872-1